Our brains constantly integrate information about both our internal state and our surroundings to determine how we behave. Much of this coordination depends on neuromodulators-chemical messengers that...
Our brains constantly integrate information about both our internal state and our surroundings to determine how we behave. Much of this coordination depends on neuromodulators-chemical messengers that...
As the human lifespan increases, so too does the risk of developing neurological disorders such as Parkinson's disease, Alzheimer's disease, anxiety and depression. These disorders are often accompani...
Brain diseases, including dementia, have long been studied using experimental animals such as mice. However, differences between the human and animal genomes have raised concerns that some disease mec...
Late-onset Alzheimer disease (AD) is a progressive disorder characterized by cognitive decline and memory impairment, affecting an estimated 6.9 million people in the U.S. The clinical course of AD un...
In people diagnosed with early-onset Alzheimer's disease, a biomarker tool that detects shrinkage of the brain's gray matter may predict how quickly someone may progress from mild cognitive impairment...
Mass General Brigham Neuroscience Institute researchers have found that a pattern of brain atrophy visible on MRI could help predict how quickly people with early-onset Alzheimer's disease progress fr...
A rare combination of lifelong cognitive tracking, postmortem brain analysis, and targeted mouse experiments reveals unexpected changes in the cells that maintain the brain’s white matter. A recent s...
By tracking every identified former NFL player who died over 14 years and examining hundreds of donated brains, researchers sought to overcome a long-standing challenge in estimating the true burden o...
The adult human brain has limited capacity to repair or regenerate neurons lost to Alzheimer's disease, the most common type of dementia. Existing treatments can slow disease progression but do not re...
In a new study from Mass General Brigham, Boston University (BU), and the Concussion & CTE Foundation, researchers found evidence that at least 1-in-4 former NFL players who died between 2016 and 2021...