Breakthroughs in Alzheimer's genetics, biomarkers, and hereditary research.
The aging brain frequently harbors multiple protein pathologies that contribute to Alzheimer's, Parkinson's and other neurodegenerative diseases. But how do these problematic proteins interact with ea...
Parkinson's disease (PD) is the second most common form of neurodegenerative disease and afflicts more than ten million people worldwide. While current therapies address disease symptoms, they do not ...
The National Institute on Aging of the National Institutes of Health has awarded a five-year grant initially worth $8.37 million for Weill Cornell Medicine researchers to study a new gene therapy for ...
Mass General Brigham, Boston University, and the Concussion & CTE Foundation cohort study of nearly 20,000 NFL players reveals that players are dying of dementia and Parkinson's disease at much higher...
Accumulation of DNA damage in the brain's neurons may contribute to the development of Alzheimer's disease. New research in FEBS Open Bio demonstrates the therapeutic potential of a drug that targets ...
As depression accelerates suffering in Alzheimer’s and Parkinson’s disease, researchers argue that the next generation of treatments must target the damaged brain circuits and molecular pathways that ...
Parkinson's disease (PD) is the second most common form of neurodegenerative disease and afflicts more than ten million people worldwide. While current therapies address disease symptoms, they do not ...
A study conducted by the Sant Pau Research Institute (IR Sant Pau) and Hospital de Sant Pau has identified for the first time in living individuals a brain pattern related to the tau protein that chan...
New research led by Mass General Brigham investigators suggests that the Bacillus Calmette-Guérin (BCG) vaccine - which is delivered through the skin to prevent tuberculosis - may remodel the human br...
A blood-based circRNA signature could help identify early Alzheimer’s biology and progression risk, offering a promising new layer beyond amyloid and tau testing. Study: Blood-based circular RNAs for...
An interdisciplinary team at the USC Center for Personalized Brain Health (CPBH) is targeting a family of enzymes that can increase the risk of inflammation in the brains of people with the APOE4 gene...
Cognitive decline in very old adults has been considered for decades to be an almost inevitable consequence of aging. In clinical practice, this has contributed to many memory problems in patients ove...
A blood test does not lie, exactly. It reports a number. The question raised by a new mini-review in Brain Medicine, which gathers and weighs a decade of scattered findings, is whether clinicians have...
Researchers at Niigata University have conducted the first comprehensive reappraisal in nearly 30 years of the risk of Alzheimer's disease (AD) associated with APOE-e4 homozygosity (e4*4) in the Japan...
Alzheimer's disease is driven by a buildup of a toxic protein called Tau that kills neurons. As toxic Tau spreads to new regions of the brain, symptoms become worse and ultimately fatal. Now, researc...
Neurodegenerative diseases affect tens of millions of people worldwide. Among these, Alzheimer's and Parkinson's diseases are the most common; in the United States alone, the Alzheimer's Disease Assoc...
Markers of a new mechanism for cell death, called karyoptosis, have been found in brains of patients with Alzheimer's disease and frontotemporal dementia (FTD). In many neurodegenerative diseases suc...
TRIMTECH Therapeutics, a biotechnology company developing novel small molecule therapies that target and degrade protein aggregates associated with neurodegenerative diseases, today announced it has r...
New research from Edith Cowan University (ECU) has discovered an important link between our genes and sleep habits, suggesting they work together to influence early brain and cognitive changes associa...
New antibiotic candidates for drug-resistant bacteria may reside inside prions, mis-folded protein in the brain best known for rare and fatal degenerative brain diseases. Prion and prion-like proteins...
Researchers at Niigata University's Brain Research Institute have uncovered a new function of amyloid precursor protein (APP), a molecule long studied as the precursor to amyloid-β (Aβ) in Alzheimer's...
Researchers at the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC analyzed brain imaging and clinical data from more than 17,000 p...
A large plasma proteomics study shows that aging patterns in specific cell types may help identify who is more vulnerable to disease and who is more resilient. Study: Plasma proteomic signatures of c...
Monash University researchers have found in laboratory experiments that a drug which delivers copper to the brain significantly reduces toxic Alzheimer's proteins and improves long-term spatial memory...
A newly identified epigenetic pathway reveals how overactive microglia may sustain brain inflammation in Alzheimer’s, suggesting KAT7 as a potential target for future therapies. Study: Epigenetic con...
A major immune pathway once known for detecting DNA damage is now being linked to brain aging, glial dysfunction, and neurodegenerative disease, raising hopes for more targeted therapies. A recent re...
Researchers in the del Monte Lab at the Medical University of South Carolina (MUSC) are the first to observe defects in the protein repair system associated with the peculiar, misfolded protein plaque...
In the coming weeks, the Human Genome and Stem Cell Research Center (HUG-CELL) will begin recruiting participants for the "Our Genes" project. The initiative aims to identify couples at an increased r...
When looking at genetic variants in a person's DNA that predispose them to disease, a new study has found having a higher number of genetic variants for increased pulse pressure is associated with a s...
A nationwide study finds that Black and Latinx adults with cognitive impairment are less likely to have Alzheimer’s-linked amyloid buildup, even as they face higher rates of dementia, raising urgent q...
Researchers at Columbia University have uncovered new clues about the earliest molecular events that may trigger Alzheimer's disease, shedding light on how toxic tau filaments begin to form in the bra...
A new brain imaging test can detect a key hallmark of Alzheimer's disease before symptoms appear and earlier than the method currently used in clinical practice in the United States and Europe, report...
For the first time, researchers found blood biomarkers for Alzheimer's disease that correlated with minor cognitive differences in midlife adults who did not have dementia. The study, led by UC San Fr...
Alzheimer's disease (AD), the leading cause of dementia, is projected to affect 152 million individuals worldwide by 2050; yet its pathogenesis remains poorly understood and effective treatments are l...
Genes undergo extensive editing through a process called alternative splicing, which greatly increases the size of the functional genome, the working portion of our DNA that helps make each person uni...
A new study offers clues as to why exercise can improve neurological symptoms in people with multiple sclerosis (MS). The study, led by investigators from Mass General Brigham and University Medical C...
DZNE researchers have generated new insights into how the human genome shapes the chemical composition and concentration of blood lipids. Across the genome, they identified more than 50 regions whose ...
Sleep complaints may be an important Alzheimer's disease risk factor in older women with a higher genetic predisposition to the disease, according to a new study from researchers at the University of ...
Monoclonal antibodies can block a key immune‑related protein that drives the spread of brain cell damage in Parkinson's disease (PD). This protein, called glycoprotein nonmetastatic melanoma B (GPNMB)...
Chromosomes carry genetic information for biological sex, which generally assigns women two X chromosomes and men XY chromosomes. This is a basic principle of human genetics most are taught in grade s...
Signs of neurodegeneration in individuals with Down syndrome may start as early as birth, a critical stage of brain development, a new study shows. The research, from investigators at the Waisman Cent...
A finger prick blood test combined with online brain testing - all done from home - could one day effectively identify people's risk of developing dementia, according to a new study. Led by the Unive...
Dementia affects over 57 million people worldwide, a number expected to nearly double in the next 20 years. This permanent loss of cognitive abilities affects daily function and can be caused by multi...
For decades, antimicrobial peptides (AMPs) and amyloid-forming peptides were studied in largely separate contexts. AMPs were viewed primarily as innate immune effectors helping the host control microb...
New research pinpoints the ages when Alzheimer’s-related brain changes accelerate, offering critical clues to when screening may be most effective. Study: Breakpoints in Alzheimer's disease biomarker...
A new research paper was published in Volume 18 of Aging-US on April 7, 2026, titled "Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer's disease neurodegeneration....
Protein droplets serve important biological functions within cells, but in neurodegenerative diseases like Alzheimer's, these liquid-like droplets can form solid-like clumps known as fibrils. This di...
Researchers at LMU have developed a human cell model that replicates key mechanisms of neurodegenerative diseases - with potential for novel therapies. Neurodegenerative dementias present one of the ...
As the body ages, cells naturally accumulate dozens of genetic mutations each year. New research from Boston Children's Hospital, published in Cell, finds that the brain's resident immune cells, micro...
Despite successfully removing amyloid plaques from the brain, widely anticipated antibody therapies fail to deliver meaningful cognitive improvements, raising critical questions about the future direc...
A new analysis of individual brain cells across several human brain regions reveals subtle but widespread differences in gene activity between male and female brains. This may help explain why some ps...
Drugs that target amyloid beta proteins in the brain likely have no clinically meaningful positive effects, while increasing the risk of bleeding and swelling in the brain, a new Cochrane review has f...
Northwestern University psychologist Andrea Russell sees older adults with early cognitive impairment riddled with anxiety. Some worry a missed word or forgotten appointment could signal Alzheimer's d...
With a new $6.2 million, five-year grant from the National Institute on Aging, researchers at Case Western Reserve University will use artificial intelligence (AI) and machine learning to identify pos...
Scientists at the Buck Institute for Research on Aging, along with collaborators at UC San Francisco, have discovered that APOE4, the most common genetic risk factor for Alzheimer's disease, causes bo...
With a NOK 40 million (approx. €3.5 million) grant, Professor Srdjan Djurovic at the University of Oslo aims to identify early blood-based biomarkers that can predict who is at increased risk of devel...
Alzheimer's disease is a progressive neurodegenerative disorder that slowly impairs memory, affects thinking skills, and eventually interferes with daily functioning. It is the most common cause of de...
Gladstone Institutes investigator Ryan Corces, PhD, has been named a 2026 winner of the Pershing Square Foundation's MIND Prize, a prestigious award recognizing next-frontier thinkers who are uncoveri...
University of Virginia School of Medicine scientists have used a next-generation form of gene editing to fix the underlying cause of a severe form of epilepsy in lab mice. Their promising results sugg...
For the millions of people who carry the gene APOE4, the strongest known genetic risk factor for Alzheimer's disease, their brain activity may begin changing long before any memory problems appear. No...
Having higher levels of vitamin D in the blood in middle age is associated with lower levels of tau protein in the brain, which is a sign of dementia, years later, according to a study published April...
A team of researchers from NYU Abu Dhabi and the University of Denver have identified a promising small molecule that could help slow or halt the progression of serious brain diseases such as Parkinso...
New research from Washington University School of Medicine in St. Louis adds to growing evidence that helping brain cells break down and eliminate their own cellular waste is a promising treatment str...
Understanding how proteins interact with their own mirror images enabled a Kobe University research team to design a small mirror protein that disables a causal factor of Alzheimer's disease, amyloid-...
A new study led by researchers at the USC Leonard Davis School of Gerontology suggests that the benefits of the Mediterranean diet may be driven, in part, by tiny proteins hidden within our mitochondr...
Alzheimer's disease is characterised by the accumulation of two proteins in the brain: amyloid-beta and tau. Tau normally stabilises the structure of nerve cells, but in this disease the protein under...
Neurodegenerative diseases form a tangled biological web with overlapping molecular signatures and symptoms. To decode this complexity, a multi-institute collaboration led by St. Jude Children's Resea...
A long-term Swedish cohort study suggests that the link between meat intake and brain aging may depend on APOE genotype, with potentially more favorable cognitive trajectories seen in older adults car...
Despite hopes raised by earlier observational studies and biomarker shifts, The Lancet trials found that oral semaglutide did not meaningfully slow clinical progression in early Alzheimer’s disease ov...
Siemens Healthineers announced today its offerings for brain health research are expanding, with the brain-derived, fully automated Atellica IM Phosphorylated tau 217 (pTau217) and Atellica IM Brain D...
Lysosomes are the control centers for the metabolism of cells and tissues, including the brain. They break down defective proteins and other macromolecules into their basic building blocks. At the sam...
Amanda Miller was 30 and pregnant with her second child in Hershey, Pennsylvania, when she developed depression. After she gave birth, her depression worsened. It was joined by a slew of unexplained h...
People with Alzheimer's disease often have other neurodegenerative conditions as well, including a less-understood disorder called frontotemporal lobar degeneration (FTLD). While a precise diagnosis o...
A certain blood protein regarded as an early indicator of Alzheimer's disease also appears to play a role in other disorders. Researchers at DZNE and the Hertie Institute for Clinical Brain Research (...
Researchers from the University of California San Diego have found that a novel blood-based biomarker can predict a woman's risk of developing dementia as many as 25 years before symptoms appear. The ...
With aging populations on the rise, the need for better tools to diagnose and monitor Alzheimer's disease (AD), the most common cause of dementia, has never been more urgent. This disease is character...
Researchers at Baylor College of Medicine have discovered a potential new strategy to fight back against Alzheimer's and Parkinson's diseases, conditions that are linked to the toxic accumulation of T...
The new generation of Alzheimer's disease drugs - the first proven to change the course of the disease - typically extend independent living for patients by 10 months. Called monoclonal antibodies, th...
Accumulation of the protein tau in the brain is one of the hallmarks of Alzheimer's disease. In a paper publishing March 5 in the Cell Press journal Cell Press Blue, researchers report a previously un...
Announcing a new article publication for BIO Integration journal. Alzheimer's disease (AD) is a neurodegenerative disorder and the leading cause of dementia worldwide. Microglia, as central nervous sy...
An Oregon State University scientist and a team of undergraduate students have uncovered real-time insights into a chemical process linked with Alzheimer's disease, paving the way toward better drug d...
This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while...
A new study suggests that a wide range of risk factors, including health and lifestyle factors, could be linked to young onset dementia. Researchers in the UK and the Netherlands studied more than 350...