Latest news on Alzheimer's clinical trials, drug testing, and new therapies.
For the first time, researchers found blood biomarkers for Alzheimer's disease that correlated with minor cognitive differences in midlife adults who did not have dementia. The study, led by UC San Fr...
A small clinical trial led by Dana-Farber Cancer Institute researchers put a Salk Institute idea to the test in patients: that activating the vitamin D receptor can help reshape the protective environ...
A largely overlooked space between cells in women's brains may hold the key to understanding memory loss tied to estrogen decline after menopause, reports a new preclinical Northwestern Medicine study...
Alzheimer's disease (AD), the leading cause of dementia, is projected to affect 152 million individuals worldwide by 2050; yet its pathogenesis remains poorly understood and effective treatments are l...
Genes undergo extensive editing through a process called alternative splicing, which greatly increases the size of the functional genome, the working portion of our DNA that helps make each person uni...
An early start to treatment is crucial to successful therapy. A new sensor is helping with early detection. For the first time, therapeutically effective medications are now available for Alzheimer's...
A new study offers clues as to why exercise can improve neurological symptoms in people with multiple sclerosis (MS). The study, led by investigators from Mass General Brigham and University Medical C...
A University of Bath-led project has secured £500,000 to develop a first-of-its-kind 'organ-on-chip' device that replicates connections between the brain, gut and pancreas. The GlucoBrain project will...
A statistical approach being used to support a new class of Alzheimer's drugs may lead to overstated claims about how the drugs work, according to a new study led by researchers at the Brown Universit...
Sleep complaints may be an important Alzheimer's disease risk factor in older women with a higher genetic predisposition to the disease, according to a new study from researchers at the University of ...
Imagine if patients with Alzheimer's could have their memories restored. Such a future may seem like a pipe dream, but a new study by researchers at Tohoku University, in collaboration with the Univer...
A healthy brain may help protect thinking and memory skills from the early effects of Alzheimer's disease, a new study has found. Dementia is currently the leading cause of death in Australia and Alz...
A simple fingerprick taken at the kitchen table and dropped in the post could soon help identify who is most at risk of Alzheimer's disease, long before symptoms tighten their grip. In a new study, r...
Signs of neurodegeneration in individuals with Down syndrome may start as early as birth, a critical stage of brain development, a new study shows. The research, from investigators at the Waisman Cent...
Lithium chloride may affect many cellular level changes in Alzheimer's disease, a new study from the University of Eastern Finland (UEF) shows. Alzheimer's disease (AD) is the most common form of dem...
A finger prick blood test combined with online brain testing - all done from home - could one day effectively identify people's risk of developing dementia, according to a new study. Led by the Unive...
For decades, antimicrobial peptides (AMPs) and amyloid-forming peptides were studied in largely separate contexts. AMPs were viewed primarily as innate immune effectors helping the host control microb...
New research pinpoints the ages when Alzheimer’s-related brain changes accelerate, offering critical clues to when screening may be most effective. Study: Breakpoints in Alzheimer's disease biomarker...
From childhood stress and pollution to sleep, inflammation, and the gut microbiome, the AHA’s new framework shows why protecting brain health must begin long before old age. Study: Brain Health Acros...
Dr. Damian Young, investigator at Texas Children's Duncan Neurological Research Institute (Duncan NRI) and director of the Center for Drug Discovery at Baylor College of Medicine, along with collabora...
As stroke severity increases, the risk of progressive cognitive decline and dementia substantially escalates, according to a national study led by Michigan Medicine researchers. People with the most ...
AlzeCure Pharma AB, a biotech company that develops candidate drugs for diseases affecting the nervous system, focusing on Alzheimer's disease and pain, today announced that the last patient’s last vi...
Scientists from Johns Hopkins Medicine report new evidence that clusters of brain tissue derived from the cells of patients with Alzheimer's disease may be used to evaluate how certain patients with t...
While some say having lots of kids can make you lose your faculties, a new study suggests otherwise.Research co-led by UT Health San Antonio, the academic health center of The University of Texas at S...
A new analysis of individual brain cells across several human brain regions reveals subtle but widespread differences in gene activity between male and female brains. This may help explain why some ps...
Drugs that target amyloid beta proteins in the brain likely have no clinically meaningful positive effects, while increasing the risk of bleeding and swelling in the brain, a new Cochrane review has f...
Loneliness affects the memory of older adults but does not speed up mental decline over time, suggests data from a major European study tracking more than 10,000 people over seven years.Participants w...
A new study finds that combining the current medications for Alzheimer's disease with small molecules derived from micronutrients found in grapes, berries, peanuts and turmeric is a safer and more eff...
Eating a higher quality plant-based diet is associated with a lower risk of Alzheimer's disease and other related dementias compared to eating a lower quality plant-based diet, according to a study pu...
Alzheimer's disease is a progressive neurodegenerative disorder that slowly impairs memory, affects thinking skills, and eventually interferes with daily functioning. It is the most common cause of de...
The National Institutes of Health has renewed support for Artificial Intelligence for Alzheimer's Disease, or AI4AD. The new $12.6 million award to advance the project's next phase, AI4AD2, brings its...
Having higher levels of vitamin D in the blood in middle age is associated with lower levels of tau protein in the brain, which is a sign of dementia, years later, according to a study published April...
The National Institutes of Health (NIH) has awarded UC Davis Health a $15.85 million grant to support the next phase of one of the nation's most extensive studies on brain aging in Hispanic-Latino com...
New research from Washington University School of Medicine in St. Louis adds to growing evidence that helping brain cells break down and eliminate their own cellular waste is a promising treatment str...
An expansive clinical trial led by USF researchers and aimed at delaying the onset of dementia continues to receive major federal support for addressing a public health crisis. The Preventing Alzheim...
A new study led by researchers at the USC Leonard Davis School of Gerontology suggests that the benefits of the Mediterranean diet may be driven, in part, by tiny proteins hidden within our mitochondr...
A new discovery by McGill researchers sheds light on how we retain memories over time, even though brain activity is constantly changing. Published in Nature, the preclinical study found the brain's ...
A long-term Swedish cohort study suggests that the link between meat intake and brain aging may depend on APOE genotype, with potentially more favorable cognitive trajectories seen in older adults car...
Despite hopes raised by earlier observational studies and biomarker shifts, The Lancet trials found that oral semaglutide did not meaningfully slow clinical progression in early Alzheimer’s disease ov...
What has long been interpreted as permanent and irreversible vascular damage may not be exclusively so. In people with Down syndrome-one of the most robust populations for studying Alzheimer's disease...
A team from the University of Barcelona has designed and validated in animal models an innovative compound with a pioneering mechanism of action for the treatment of Alzheimer's disease. Unlike curren...
A powerful new real-world data platform could transform how scientists predict and understand Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD), reports a new study at Columbia U...
People with Alzheimer's disease often have other neurodegenerative conditions as well, including a less-understood disorder called frontotemporal lobar degeneration (FTLD). While a precise diagnosis o...
A team of researchers at the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC has identified important differences in how early Alzh...
Researchers from the University of California San Diego have found that a novel blood-based biomarker can predict a woman's risk of developing dementia as many as 25 years before symptoms appear. The ...
A new study led by researchers from VIB and KU Leuven shows that immune cells called microglia can actively promote the formation of plaques in Alzheimer's disease, challenging the long-standing view ...
The new generation of Alzheimer's disease drugs - the first proven to change the course of the disease - typically extend independent living for patients by 10 months. Called monoclonal antibodies, th...
Aging in later life is often portrayed as a steady slide toward physical and cognitive decline. But a new study by scientists at Yale University suggests an alternate narrative - that older individual...
Accumulation of the protein tau in the brain is one of the hallmarks of Alzheimer's disease. In a paper publishing March 5 in the Cell Press journal Cell Press Blue, researchers report a previously un...
An exploratory clinical trial from the University of Pittsburgh suggests that low‑dose oral lithium may help slow the decline of verbal memory, or ability to remember and recall words and sentences, i...
A small but growing body of evidence suggests that a minimally invasive surgical procedure called lymphovenous anastomosis (LVA) might be an effective treatment for Alzheimer's disease (AD), according...
Brains of older adults with super healthy cognition grow more new neurons than those of their peers, according to a study from UIC, Northwestern University and the University of Washington. Researcher...
A decade ago, the dementia treatment landscape looked bleak. Disease‑modifying therapies felt distant, and many promising discoveries emerging from UK universities struggled to progress towards clinic...
Researchers at Washington University School of Medicine in St. Louis have received an $80 million grant to continue research into the mysteries of exceptional longevity. The grant renews support for t...
An Oregon State University scientist and a team of undergraduate students have uncovered real-time insights into a chemical process linked with Alzheimer's disease, paving the way toward better drug d...
Subtle changes in how blood flows through the brain and how brain tissue uses oxygen may be closely linked to Alzheimer's disease risk, according to new research from the Mark and Mary Stevens Neuroim...
This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while...
This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while...
Regulators across the world are grappling with what to do about new medicines for early Alzheimer’s disease. Today, an expert committee for the European regulator the European Medicines Agency (EMA) d...
Monday’s BBC Panorama episode – “Alzheimer’s: A Turning Point?” – focused on the potential arrival of two new breakthrough treatments for Alzheimer’s disease, lecanemab and donanemab. In the past two ...
Drugs used to treat erectile dysfunction could also be linked to a reduced risk of developing Alzheimer’s disease, according to new research from University College London. The findings have been publ...
The pharmaceutical company, Biogen, announced this week that it will stop developing and marketing the Alzheimer’s drug aducanumab (commercially known as Aduhelm). Aducanumab is designed to target an...
New research, published today in Nature Medicine, has identified five cases of Alzheimer’s disease believed to have arisen because of a medical treatment decades earlier. These individuals had all bee...
Today the government announced that £49.9 million will go towards expanding the number of dementia research sites across the UK. This will give more people the chance to take part in clinical trials, ...
A new study suggests that a wide range of risk factors, including health and lifestyle factors, could be linked to young onset dementia. Researchers in the UK and the Netherlands studied more than 350...
Research suggests that social isolation is linked to an increased risk of dementia. So keeping connected to the people around us is another good way to give back to our brains. A recent study showed ...