Latest news on Alzheimer's clinical trials, drug testing, and new therapies.
A small wireless patch captured water-sensitive brain signals through natural sleep, opening a potential path to home-based research into how sleep stages shape brain-fluid dynamics. Study: A soft we...
Alcohol use has been associated with an increased risk of cognitive decline and dementia. But new research from the Texas A&M University Naresh K. Vashisht College of Medicine at Texas A&M Health sugg...
People diagnosed with early-onset dementia had reduced work productivity up to 15 years before diagnosis, according to a study published July 8, 2026, in Neurology®, the medical journal of the America...
Alzheimer’s Disease International (ADI) has launched the Alzheimer’s Disease Atlas (AD Atlas), a first of its kind platform highlighting how countries diagnose, treat and support people living with de...
The aging brain frequently harbors multiple protein pathologies that contribute to Alzheimer's, Parkinson's and other neurodegenerative diseases. But how do these problematic proteins interact with ea...
Parkinson's disease (PD) is the second most common form of neurodegenerative disease and afflicts more than ten million people worldwide. While current therapies address disease symptoms, they do not ...
The National Institute on Aging of the National Institutes of Health has awarded a five-year grant initially worth $8.37 million for Weill Cornell Medicine researchers to study a new gene therapy for ...
Mass General Brigham, Boston University, and the Concussion & CTE Foundation cohort study of nearly 20,000 NFL players reveals that players are dying of dementia and Parkinson's disease at much higher...
Accumulation of DNA damage in the brain's neurons may contribute to the development of Alzheimer's disease. New research in FEBS Open Bio demonstrates the therapeutic potential of a drug that targets ...
As depression accelerates suffering in Alzheimer’s and Parkinson’s disease, researchers argue that the next generation of treatments must target the damaged brain circuits and molecular pathways that ...
The King's College London study, published in Nature Communications, offers insight into how long-term inflammation may contribute to cognitive decline in disorders such as Alzheimer's disease, aging,...
A large Chinese cohort study suggests that sleep patterns, especially short sleep and poor sleep quality, may help identify people at higher risk of Parkinson’s disease before clinical diagnosis. Stu...
Parkinson's disease (PD) is the second most common form of neurodegenerative disease and afflicts more than ten million people worldwide. While current therapies address disease symptoms, they do not ...
New in JNeurosci, Xia Zhang, from the Max Planck Institute for Human Cognitive and Brain Sciences, led a study exploring the relationship between heart issues and cognitive function. The researchers ...
A study conducted by the Sant Pau Research Institute (IR Sant Pau) and Hospital de Sant Pau has identified for the first time in living individuals a brain pattern related to the tau protein that chan...
A blood-based circRNA signature could help identify early Alzheimer’s biology and progression risk, offering a promising new layer beyond amyloid and tau testing. Study: Blood-based circular RNAs for...
A substance that worsens dementia has become a "switch" that initiates treatment. KAIST researchers have developed a new therapeutic approach that uses hydrogen peroxide (H₂O₂), a reactive oxygen spec...
New research using smartwatches shows that older adults can accurately assess how well they are thinking in the moment. The study finds their self-ratings closely match actual cognitive performance. ...
Researchers at Niigata University have conducted the first comprehensive reappraisal in nearly 30 years of the risk of Alzheimer's disease (AD) associated with APOE-e4 homozygosity (e4*4) in the Japan...
High-dose DHA successfully reached the brains of older adults at increased risk of Alzheimer's disease, but the two-year clinical trial found no improvements in memory or brain structure, challenging ...
A new USC-led study finds Alzheimer's disease and related dementias will cost the United States an estimated $818 billion this year, driven largely by often-overlooked costs to persons living with dem...
Laughter is a universal social signal that connects us with others, but the brain regions underlying laughter are not well understood, in part because it's hard to elicit genuine laughter in the lab. ...
A postmortem multi-omics study suggests that long-standing traits such as neuroticism, loneliness, and purpose in life may track distinct molecular routes through Alzheimer’s dementia, offering clues ...
New research from Edith Cowan University (ECU) has discovered an important link between our genes and sleep habits, suggesting they work together to influence early brain and cognitive changes associa...
New antibiotic candidates for drug-resistant bacteria may reside inside prions, mis-folded protein in the brain best known for rare and fatal degenerative brain diseases. Prion and prion-like proteins...
Researchers at the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC analyzed brain imaging and clinical data from more than 17,000 p...
A large plasma proteomics study shows that aging patterns in specific cell types may help identify who is more vulnerable to disease and who is more resilient. Study: Plasma proteomic signatures of c...
Often called "the window to the soul," the eyes may also offer clues about something less poetic but just as important: the health of the brain. A new study of tens of thousands of patients revealed ...
Scientists have long known that being obese increases the risk of dementia and Alzheimer's disease. What remains unclear is how that risk develops in the brain. Virginia Tech neuroscientist Timothy J...
Monash University researchers have found in laboratory experiments that a drug which delivers copper to the brain significantly reduces toxic Alzheimer's proteins and improves long-term spatial memory...
Long viewed mainly as a movement center, the cerebellum may play a critical role in cognitive resilience, with new MRI evidence linking its structure to sharper thinking in later life. Study: Cerebel...
A newly identified epigenetic pathway reveals how overactive microglia may sustain brain inflammation in Alzheimer’s, suggesting KAT7 as a potential target for future therapies. Study: Epigenetic con...
Women are twice as likely as men to develop post-traumatic stress disorder (PTSD) - and new research may offer a biological clue as to why. A Virginia Tech study found that the female brain forms fea...
In 2025, the European Medicines Agency approved two antibodies for Alzheimer's disease: lecanemab (LeqembiTM, from Biogen) and donanemab (KisunlaTM, from Eli Lilly and Company), both based on immunoth...
When looking at genetic variants in a person's DNA that predispose them to disease, a new study has found having a higher number of genetic variants for increased pulse pressure is associated with a s...
A new study by researchers at UC Davis Health and Kaiser Permanente found that higher exposure to very small air pollution particles (PM2.5) over a 17-year span was associated with lower semantic memo...
The brain may reuse some cells to store many different memories without mixing them up with or erasing older memories, a new study in mice suggests. Led by NYU Langone Health researchers, the study r...
Paralysis on one side of the body is common after stroke. A new study in CNS Neuroscience & Therapeutics demonstrates that acupuncture can significantly improve muscle function recovery in patients wh...
A nationwide study finds that Black and Latinx adults with cognitive impairment are less likely to have Alzheimer’s-linked amyloid buildup, even as they face higher rates of dementia, raising urgent q...
New Alzheimer’s drugs are raising hopes, but modest benefits, ARIA safety risks, high costs, and regulatory disagreements show how uncertain the path to meaningful treatment remains. From hope to unc...
For the first time, researchers found blood biomarkers for Alzheimer's disease that correlated with minor cognitive differences in midlife adults who did not have dementia. The study, led by UC San Fr...
A small clinical trial led by Dana-Farber Cancer Institute researchers put a Salk Institute idea to the test in patients: that activating the vitamin D receptor can help reshape the protective environ...
A largely overlooked space between cells in women's brains may hold the key to understanding memory loss tied to estrogen decline after menopause, reports a new preclinical Northwestern Medicine study...
Alzheimer's disease (AD), the leading cause of dementia, is projected to affect 152 million individuals worldwide by 2050; yet its pathogenesis remains poorly understood and effective treatments are l...
Genes undergo extensive editing through a process called alternative splicing, which greatly increases the size of the functional genome, the working portion of our DNA that helps make each person uni...
An early start to treatment is crucial to successful therapy. A new sensor is helping with early detection. For the first time, therapeutically effective medications are now available for Alzheimer's...
A new study offers clues as to why exercise can improve neurological symptoms in people with multiple sclerosis (MS). The study, led by investigators from Mass General Brigham and University Medical C...
A University of Bath-led project has secured £500,000 to develop a first-of-its-kind 'organ-on-chip' device that replicates connections between the brain, gut and pancreas. The GlucoBrain project will...
A statistical approach being used to support a new class of Alzheimer's drugs may lead to overstated claims about how the drugs work, according to a new study led by researchers at the Brown Universit...
Sleep complaints may be an important Alzheimer's disease risk factor in older women with a higher genetic predisposition to the disease, according to a new study from researchers at the University of ...
Imagine if patients with Alzheimer's could have their memories restored. Such a future may seem like a pipe dream, but a new study by researchers at Tohoku University, in collaboration with the Univer...
A healthy brain may help protect thinking and memory skills from the early effects of Alzheimer's disease, a new study has found. Dementia is currently the leading cause of death in Australia and Alz...
A simple fingerprick taken at the kitchen table and dropped in the post could soon help identify who is most at risk of Alzheimer's disease, long before symptoms tighten their grip. In a new study, r...
Signs of neurodegeneration in individuals with Down syndrome may start as early as birth, a critical stage of brain development, a new study shows. The research, from investigators at the Waisman Cent...
Lithium chloride may affect many cellular level changes in Alzheimer's disease, a new study from the University of Eastern Finland (UEF) shows. Alzheimer's disease (AD) is the most common form of dem...
A finger prick blood test combined with online brain testing - all done from home - could one day effectively identify people's risk of developing dementia, according to a new study. Led by the Unive...
For decades, antimicrobial peptides (AMPs) and amyloid-forming peptides were studied in largely separate contexts. AMPs were viewed primarily as innate immune effectors helping the host control microb...
New research pinpoints the ages when Alzheimer’s-related brain changes accelerate, offering critical clues to when screening may be most effective. Study: Breakpoints in Alzheimer's disease biomarker...
From childhood stress and pollution to sleep, inflammation, and the gut microbiome, the AHA’s new framework shows why protecting brain health must begin long before old age. Study: Brain Health Acros...
Dr. Damian Young, investigator at Texas Children's Duncan Neurological Research Institute (Duncan NRI) and director of the Center for Drug Discovery at Baylor College of Medicine, along with collabora...
As stroke severity increases, the risk of progressive cognitive decline and dementia substantially escalates, according to a national study led by Michigan Medicine researchers. People with the most ...
AlzeCure Pharma AB, a biotech company that develops candidate drugs for diseases affecting the nervous system, focusing on Alzheimer's disease and pain, today announced that the last patient’s last vi...
Scientists from Johns Hopkins Medicine report new evidence that clusters of brain tissue derived from the cells of patients with Alzheimer's disease may be used to evaluate how certain patients with t...
While some say having lots of kids can make you lose your faculties, a new study suggests otherwise.Research co-led by UT Health San Antonio, the academic health center of The University of Texas at S...
A new analysis of individual brain cells across several human brain regions reveals subtle but widespread differences in gene activity between male and female brains. This may help explain why some ps...
Drugs that target amyloid beta proteins in the brain likely have no clinically meaningful positive effects, while increasing the risk of bleeding and swelling in the brain, a new Cochrane review has f...
Loneliness affects the memory of older adults but does not speed up mental decline over time, suggests data from a major European study tracking more than 10,000 people over seven years.Participants w...
A new study finds that combining the current medications for Alzheimer's disease with small molecules derived from micronutrients found in grapes, berries, peanuts and turmeric is a safer and more eff...
Eating a higher quality plant-based diet is associated with a lower risk of Alzheimer's disease and other related dementias compared to eating a lower quality plant-based diet, according to a study pu...
Alzheimer's disease is a progressive neurodegenerative disorder that slowly impairs memory, affects thinking skills, and eventually interferes with daily functioning. It is the most common cause of de...
The National Institutes of Health has renewed support for Artificial Intelligence for Alzheimer's Disease, or AI4AD. The new $12.6 million award to advance the project's next phase, AI4AD2, brings its...
Having higher levels of vitamin D in the blood in middle age is associated with lower levels of tau protein in the brain, which is a sign of dementia, years later, according to a study published April...
The National Institutes of Health (NIH) has awarded UC Davis Health a $15.85 million grant to support the next phase of one of the nation's most extensive studies on brain aging in Hispanic-Latino com...
New research from Washington University School of Medicine in St. Louis adds to growing evidence that helping brain cells break down and eliminate their own cellular waste is a promising treatment str...
An expansive clinical trial led by USF researchers and aimed at delaying the onset of dementia continues to receive major federal support for addressing a public health crisis. The Preventing Alzheim...
A new study led by researchers at the USC Leonard Davis School of Gerontology suggests that the benefits of the Mediterranean diet may be driven, in part, by tiny proteins hidden within our mitochondr...
A new discovery by McGill researchers sheds light on how we retain memories over time, even though brain activity is constantly changing. Published in Nature, the preclinical study found the brain's ...
A long-term Swedish cohort study suggests that the link between meat intake and brain aging may depend on APOE genotype, with potentially more favorable cognitive trajectories seen in older adults car...
Despite hopes raised by earlier observational studies and biomarker shifts, The Lancet trials found that oral semaglutide did not meaningfully slow clinical progression in early Alzheimer’s disease ov...
What has long been interpreted as permanent and irreversible vascular damage may not be exclusively so. In people with Down syndrome-one of the most robust populations for studying Alzheimer's disease...
A team from the University of Barcelona has designed and validated in animal models an innovative compound with a pioneering mechanism of action for the treatment of Alzheimer's disease. Unlike curren...
A powerful new real-world data platform could transform how scientists predict and understand Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD), reports a new study at Columbia U...
People with Alzheimer's disease often have other neurodegenerative conditions as well, including a less-understood disorder called frontotemporal lobar degeneration (FTLD). While a precise diagnosis o...
A team of researchers at the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC has identified important differences in how early Alzh...
Researchers from the University of California San Diego have found that a novel blood-based biomarker can predict a woman's risk of developing dementia as many as 25 years before symptoms appear. The ...
A new study led by researchers from VIB and KU Leuven shows that immune cells called microglia can actively promote the formation of plaques in Alzheimer's disease, challenging the long-standing view ...
The new generation of Alzheimer's disease drugs - the first proven to change the course of the disease - typically extend independent living for patients by 10 months. Called monoclonal antibodies, th...
Aging in later life is often portrayed as a steady slide toward physical and cognitive decline. But a new study by scientists at Yale University suggests an alternate narrative - that older individual...
Accumulation of the protein tau in the brain is one of the hallmarks of Alzheimer's disease. In a paper publishing March 5 in the Cell Press journal Cell Press Blue, researchers report a previously un...
An exploratory clinical trial from the University of Pittsburgh suggests that low‑dose oral lithium may help slow the decline of verbal memory, or ability to remember and recall words and sentences, i...
A small but growing body of evidence suggests that a minimally invasive surgical procedure called lymphovenous anastomosis (LVA) might be an effective treatment for Alzheimer's disease (AD), according...
Brains of older adults with super healthy cognition grow more new neurons than those of their peers, according to a study from UIC, Northwestern University and the University of Washington. Researcher...
A decade ago, the dementia treatment landscape looked bleak. Disease‑modifying therapies felt distant, and many promising discoveries emerging from UK universities struggled to progress towards clinic...
Researchers at Washington University School of Medicine in St. Louis have received an $80 million grant to continue research into the mysteries of exceptional longevity. The grant renews support for t...
An Oregon State University scientist and a team of undergraduate students have uncovered real-time insights into a chemical process linked with Alzheimer's disease, paving the way toward better drug d...
Subtle changes in how blood flows through the brain and how brain tissue uses oxygen may be closely linked to Alzheimer's disease risk, according to new research from the Mark and Mary Stevens Neuroim...
This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while...
This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while...
Regulators across the world are grappling with what to do about new medicines for early Alzheimer’s disease. Today, an expert committee for the European regulator the European Medicines Agency (EMA) d...
Monday’s BBC Panorama episode – “Alzheimer’s: A Turning Point?” – focused on the potential arrival of two new breakthrough treatments for Alzheimer’s disease, lecanemab and donanemab. In the past two ...
Drugs used to treat erectile dysfunction could also be linked to a reduced risk of developing Alzheimer’s disease, according to new research from University College London. The findings have been publ...
The pharmaceutical company, Biogen, announced this week that it will stop developing and marketing the Alzheimer’s drug aducanumab (commercially known as Aduhelm). Aducanumab is designed to target an...
New research, published today in Nature Medicine, has identified five cases of Alzheimer’s disease believed to have arisen because of a medical treatment decades earlier. These individuals had all bee...
Today the government announced that £49.9 million will go towards expanding the number of dementia research sites across the UK. This will give more people the chance to take part in clinical trials, ...
A new study suggests that a wide range of risk factors, including health and lifestyle factors, could be linked to young onset dementia. Researchers in the UK and the Netherlands studied more than 350...
Research suggests that social isolation is linked to an increased risk of dementia. So keeping connected to the people around us is another good way to give back to our brains. A recent study showed ...